Yi Fu  Tenure-track Associate Professor

Contact Information

Tel: 010-82805027

Email: yi.fu@bjmu.edu.cn

Research Direction

The inflammatory microenvironment regulates the pathogenesis of major vascular disease

Personal Profile

Yi Fu is a Tenure-track Associate Professor in the Department of Physiology and Pathophysiology at the Peking University Health Science Center, and a recipient of the Peking University Boya Young Scholar distinction. His primary research focuses on the mechanisms by which the inflammatory microenvironment regulates the pathogenesis of major vascular diseases.

Key academic achievements include:

① Identifying novel pro-inflammatory cell types in the vascular microenvironment—such as intimal-resident macrophages—and elucidating the specific regulatory mechanisms of platelets as non-classical immune cells (J Clin Invest. 2025; Nat Cardiovasc Res. 2023; Cardiovasc Res. 2025; Circ Res. 2016);

② Discovering new extracellular bioactive molecules that modulate inflammation, including the endothelial cell-derived pro-inflammatory molecule FAM3D, which expands the understanding of inflammatory mediators. He has also investigated anti-inflammatory molecules, revealing novel negative regulatory mechanisms (Cell Rep Med. 2023; J Am Soc Nephrol. 2023; Circulation 2023; Cell Res. 2021).

He has been supported by the National Natural Science Foundation of China (NSFC) Excellent Young Scientists Fund and received awards including the First Prize in Natural Science from the Ministry of Education.

He currently serves as Vice Chair of the Young Investigators Committee of the Chinese Association for Physiological Sciences, member of the Matrix Biology Committee, and member of the Cardiovascular Immunology Branch of the Chinese Society of Immunology.

Experience

Education:

1999-2004 West China School of Medicine, Sichuan University — Bachelor of Clinical Medicine

2004-2009 School of Basic Medical Sciences, Peking University — Ph.D. in Physiology

Work Experience:

2009-2012 Baker IDI Heart and Diabetes Institute, Australia — Postdoctoral Fellow in Vascular Pharmacology

2012-2016 Department of Physiology and Pathophysiology, Peking University Health Science Center — Lecturer

2016-2021 Department of Physiology and Pathophysiology, Peking University Health Science Center — Associate Professor

2021-Present Department of Physiology and Pathophysiology, Peking University Health Science Center — Tenure-track Associate Professor

Representative Publications

1. Huang J, Liu H, Liu Z, Wang Z, Xu H, Li Z, Huang S, Yang X, Shen Y, Yu F, Li Y, Zhu J, Li W, Wang L, Kong W, Fu Y. Inhibition of aortic CX3CR1+ macrophages mitigates thoracic aortic aneurysm progression in Marfan syndrome in mice. J Clin Invest. 2025 Jan 16;135(2):e178198.

2. Dong Z, Jin Y, Shen Y, Huang J, Tan J, Feng Q, Gong Z, Zhu S, Chen H, Yu F, Li W, Jia Y, Kong W, Fu Y. Methyltransferase-like 3-catalysed N6-methyladenosine methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis. Cardiovasc Res. 2025 May 6;121(4):568-584.

3. Huang J, Feng Q, Dong Z, Li Z, Liu Y, Xu R, Liu Z, Ding Q, Yang X, Yu F, Jia Y, Zhou Y, Kong W, Tang H, Fu Y. METTL3 Exacerbates Intimal Hyperplasia by Facilitating m6A-YTHDC1-Dependent SGK1 Gene Transcription. Arterioscler Thromb Vasc Biol. 2025 Sep;45(9):e437-e453.

4. Shen Y, Dong Z, Fan F, Li K, Zhu S, Dai R, Huang J, Xie N, He L, Gong Z, Yang X, Tan J, Liu L, Yu F, Tang Y, You Z, Xi J, Wang Y, Kong W, Zhang Y, Fu Y. Targeting cytokine-like protein FAM3D lowers blood pressure in hypertension. Cell Rep Med. 2023 Jun 20;4(6):101072.

5. Ma Z, Mao C, Jia Y, Yu F, Xu P, Tan Y, Zou QH, Zhou XJ, Kong W, Fu Y. ADAMTS7-Mediated Complement Factor H Degradation Potentiates Complement Activation to Contributing to Renal Injuries. J Am Soc Nephrol. 2023 Feb 1;34(2):291-308.